<?xml version="1.0"?>
<RDF:RDF xmlns:dc="http://purl.org/dc/elements/1.1/"
         xmlns:bm="http://www.w3.org/2002/01/bookmark#"
         xmlns:a="http://www.w3.org/2000/10/annotation-ns#"
         xmlns:foaf="http://xmlns.com/foaf/0.1/"
         xmlns:pres="http://www.w3.org/2001/Annotea/schemas/2006/04/presentation#"
         xmlns:OWL="http://www.w3.org/2002/07/owl#"
         xmlns:RDFS="http://www.w3.org/2000/01/rdf-schema#"
         xmlns:NC="http://home.netscape.com/NC-rdf#"
         xmlns:RDF="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_02_41_42_GMT"
                   a:created="Wed, 01 Nov 2006 02:41:28 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:title="Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway."
                   dc:date="Wed, 01 Nov 2006 03:12:31 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=14966292&amp;dopt=Abstract"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_03_08_25_GMT"/>
  </bm:Bookmark>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_03_08_25_GMT"
                   dc:title="p14ARF-p53"
                   dc:date="Wed, 01 Nov 2006 03:08:06 GMT"
                   a:created="Wed, 01 Nov 2006 03:08:06 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_09_44_GMT"
                   dc:title="Genes"
                   a:created="Thu, 12 Oct 2006 14:09:33 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:date="Thu, 12 Oct 2006 22:41:42 GMT">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
  </bm:Topic>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_20_20_GMT"
                   dc:title="APC - References - Genetics Home Reference"
                   dc:date="Thu, 12 Oct 2006 14:20:07 GMT"
                   a:created="Thu, 12 Oct 2006 14:20:07 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <bm:recalls RDF:resource="http://ghr.nlm.nih.gov/gene=apc/show/References"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_03_03_07_GMT"
                   a:created="Wed, 01 Nov 2006 03:02:59 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:title="Distribution of TP53 mutations among acute leukemias with MLL rearrangements."
                   dc:date="Wed, 01 Nov 2006 03:10:08 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&amp;db=pubmed&amp;cmd=Retrieve&amp;dopt=abstractplus&amp;list_uids=8824725"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_36_14_GMT"
                   dc:title="PharmGKB: MTUS1"
                   a:created="Thu, 12 Oct 2006 14:36:03 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:date="Thu, 02 Nov 2006 21:04:52 GMT">
    <bm:recalls RDF:resource="http://www.pharmgkb.org/do/serve?objId=PA134968054&amp;objCls=Gene"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_35_58_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_14_04_GMT"
                   dc:title="APC (adenomatous polyposis coli)"
                   a:created="Thu, 12 Oct 2006 14:13:54 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:date="Wed, 01 Nov 2006 02:24:55 GMT">
    <bm:recalls RDF:resource="http://atlasgeneticsoncology.org/Genes/APC118.html"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"/>
  </bm:Bookmark>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_47_10_GMT"
                   a:created="Thu, 12 Oct 2006 13:46:52 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:title="TCF21"
                   dc:date="Thu, 12 Oct 2006 14:24:36 GMT">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_09_44_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_35_58_GMT"
                   dc:title="MTUS1"
                   a:created="Thu, 12 Oct 2006 14:35:32 GMT"
                   dc:description="Mitoconndriac tumor suppressor"
                   dc:creator="Marja"
                   dc:date="Thu, 02 Nov 2006 21:04:05 GMT">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_09_44_GMT"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_39_38_GMT"
                   dc:title="cdk2"
                   a:created="Thu, 02 Nov 2006 21:39:18 GMT"
                   dc:creator="Marja"
                   dc:description="cell division-stimulating protein "
                   dc:date="Thu, 02 Nov 2006 21:40:16 GMT">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_02_45_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"
                   dc:title="APC"
                   a:created="Thu, 12 Oct 2006 14:12:05 GMT"
                   dc:description="Adenomatous polyposis coli (APC) gene"
                   dc:creator="Marja"
                   dc:date="Wed, 01 Nov 2006 02:24:10 GMT">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_09_44_GMT"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
  </bm:Topic>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_15_36_09_GMT"
                   dc:title="Regulation of tumor suppressors by nuclear-cytoplasmic shuttling."
                   dc:date="Thu, 12 Oct 2006 15:35:15 GMT"
                   a:created="Thu, 12 Oct 2006 15:35:15 GMT"
                   dc:description="umor suppressor proteins control the proliferation and survival of normal cells; consequently, their inactivation by gene mutations can initiate or drive cancer progression. Most tumor suppressors have been identified by genetic screening, and in many cases their function and regulation are poorly understood. Ten such proteins were recently shown to contain nuclear transport signals that facilitate their &quot;shuttling&quot; between the nucleus and cytoplasm. This type of dynamic intracellular movement not only regulates protein localization, but also often impacts on function. Here, we review the pathways by which tumor suppressors such as APC, p53, VHL, and BRCA1 cross the nuclear envelope and the impact of regulated nuclear import/export on protein function."
                   dc:creator="Marja">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&amp;cmd=Retrieve&amp;db=PubMed&amp;list_uids=12531692&amp;dopt=Abstract"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_27_17_GMT"
                   dc:title="PharmGKB: TP53"
                   dc:date="Thu, 12 Oct 2006 14:27:07 GMT"
                   a:created="Thu, 12 Oct 2006 14:27:07 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <bm:recalls RDF:resource="http://www.pharmgkb.org/do/serve?objId=PA36679&amp;objCls=Gene"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
  </bm:Bookmark>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_02_45_GMT"
                   dc:title="Proteins"
                   dc:date="Thu, 02 Nov 2006 21:02:17 GMT"
                   a:created="Thu, 02 Nov 2006 21:02:17 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
  </bm:Topic>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_03_02_11_GMT"
                   a:created="Wed, 01 Nov 2006 03:00:56 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:title="Functional inactivation of P53 as a potential mechanism of MLL leukemogenesis."
                   dc:date="Wed, 01 Nov 2006 03:10:45 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17062917&amp;query_hl=5&amp;itool=pubmed_docsum"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Bookmark>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_10_11_GMT"
                   dc:title="EB1"
                   dc:date="Thu, 02 Nov 2006 21:09:53 GMT"
                   a:created="Thu, 02 Nov 2006 21:09:53 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_02_45_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_20_47_GMT"
                   dc:title="p53 signaling pathway"
                   dc:date="Thu, 02 Nov 2006 21:20:19 GMT"
                   a:created="Thu, 02 Nov 2006 21:20:19 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_37_06_GMT"
                   dc:title="p21"
                   dc:date="Thu, 02 Nov 2006 21:36:19 GMT"
                   a:created="Thu, 02 Nov 2006 21:36:19 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_02_45_GMT"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"
                   dc:title="Pathways"
                   dc:date="Wed, 01 Nov 2006 01:58:16 GMT"
                   a:created="Wed, 01 Nov 2006 01:58:16 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"
                   dc:title="Tumor suppressors"
                   a:created="Thu, 12 Oct 2006 13:39:39 GMT"
                   dc:creator="Marja"
                   dc:description="General information about tumor suppressor genes or proteins"
                   dc:date="Thu, 02 Nov 2006 21:27:35 GMT">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"
                   dc:title="P53"
                   dc:date="Thu, 12 Oct 2006 14:26:46 GMT"
                   a:created="Thu, 12 Oct 2006 14:26:46 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_09_44_GMT"/>
  </bm:Topic>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_19_24_GMT"
                   dc:title="The importance of APC"
                   a:created="Thu, 12 Oct 2006 14:18:20 GMT"
                   dc:description="Journal of Autoimmune diseases"
                   dc:creator="Marja"
                   dc:date="Thu, 12 Oct 2006 14:20:39 GMT">
    <bm:recalls RDF:resource="http://www.jautoimdis.com/content/2/1/3"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_13_43_41_GMT"
                   dc:title="PharmGKB: TCF21"
                   a:created="Thu, 12 Oct 2006 13:43:06 GMT"
                   dc:description="Lung cancer suppressor gene"
                   dc:creator="Marja"
                   dc:date="Thu, 12 Oct 2006 13:47:27 GMT">
    <bm:recalls RDF:resource="http://www.pharmgkb.org/do/serve?objId=PA36387&amp;objCls=Gene"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_47_10_GMT"/>
  </bm:Bookmark>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_41_59_GMT"
                   dc:title="Diseases"
                   dc:date="Thu, 02 Nov 2006 21:41:36 GMT"
                   a:created="Thu, 02 Nov 2006 21:41:36 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
  </bm:Topic>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_20_01_GMT"
                   dc:title="RB1/p16"
                   dc:date="Thu, 02 Nov 2006 21:19:41 GMT"
                   a:created="Thu, 02 Nov 2006 21:19:41 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Topic>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_13_46_45_GMT"
                   a:created="Thu, 12 Oct 2006 13:46:22 GMT"
                   dc:creator="Marja"
                   dc:title="Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer."
                   dc:description="Report of an application of restriction landmark genomic scanning that allows for DNA methylation profiling along a region of recurrent loss of heterozygosity at chromosome 6q23-q24. This approach resulted in the identification of a tumor suppressor gene, TCF21, which is frequently lost in human malignancies. We demonstrate that TCF21 is expressed in normal lung airway epithelial cells and aberrantly methylated and silenced in the majority of head and neck squamous cell carcinomas and non-small-cell lung cancers analyzed. TCF21 is known to regulate mesenchymal cell transition into epithelial cells, a property that has been shown to be deficient in carcinomas. We further demonstrate that exogenous expression of TCF21 in cells that have silenced the endogenous TCF21 locus resulted in a reduction of tumor properties in vitro and in vivo."
                   dc:date="Thu, 12 Oct 2006 14:07:52 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=16415157"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_47_10_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_16_09_GMT"
                   dc:title="EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle."
                   a:created="Thu, 12 Oct 2006 14:14:37 GMT"
                   dc:description="By immunocytochemistry EB1 was shown to be closely associated with the microtubule cytoskeleton throughout the cell cycle."
                   dc:creator="Marja"
                   dc:date="Thu, 02 Nov 2006 21:10:34 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10030671&amp;dopt=Abstract"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_10_11_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_02_58_27_GMT"
                   a:created="Wed, 01 Nov 2006 02:57:48 GMT"
                   dc:creator="Marja"
                   dc:title="Entrez PubMed: Epigenetic abnormalities in cutaneous squamous cell carcinomas"
                   dc:description="Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways."
                   dc:date="Thu, 02 Nov 2006 21:19:27 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17034532&amp;query_hl=2&amp;itool=pubmed_DocSum"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_07_16_GMT"
                   dc:title="RGD Gene Report: Tcf21 (RGD: 620523)"
                   dc:date="Thu, 12 Oct 2006 14:06:41 GMT"
                   a:created="Thu, 12 Oct 2006 14:06:41 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <bm:recalls RDF:resource="http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620523"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_47_10_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_13_40_15_GMT"/>
  </bm:Bookmark>
  <bm:Topic RDF:about="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_42_25_GMT"
                   dc:title="Li-Fraumeni syndrome"
                   dc:date="Thu, 02 Nov 2006 21:42:07 GMT"
                   a:created="Thu, 02 Nov 2006 21:42:07 GMT"
                   dc:description=""
                   dc:creator="Marja">
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:subTopicOf RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_41_59_GMT"/>
  </bm:Topic>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_21_36_GMT"
                   dc:title="PharmGKB: APC"
                   a:created="Thu, 12 Oct 2006 14:21:30 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:date="Wed, 01 Nov 2006 02:25:37 GMT">
    <bm:recalls RDF:resource="http://www.pharmgkb.org/do/serve?objId=PA24875&amp;objCls=Gene"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"/>
  </bm:Bookmark>
  <foaf:Person RDF:about="http://www.annotea.org/marja#marja" />
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_02_37_28_GMT"
                   a:created="Wed, 01 Nov 2006 02:36:58 GMT"
                   dc:description=""
                   dc:creator="Marja"
                   dc:title="Mechanism of benzo(a)pyrene-induced accumulation of p53 tumour suppressor protein in mouse"
                   dc:date="Wed, 01 Nov 2006 03:11:28 GMT">
    <bm:recalls RDF:resource="http://herkules.oulu.fi/isbn9514270398/html/x243.html"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_03_19_49_GMT"
                   a:created="Wed, 01 Nov 2006 03:19:26 GMT"
                   dc:creator="Marja"
                   dc:title="BioCarta:  p53 Signaling Pathway"
                   dc:description=" p53 Signaling Pathway"
                   dc:date="Thu, 02 Nov 2006 21:21:22 GMT">
    <bm:recalls RDF:resource="http://www.biocarta.com/pathfiles/h_p53Pathway.asp"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_02_Nov_2006_21_20_47_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Thu_12_Oct_2006_14_17_51_GMT"
                   dc:title="The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase."
                   a:created="Thu, 12 Oct 2006 14:16:29 GMT"
                   dc:description="The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in many sporadic colorectal tumors. The carboxyl-terminal S/TXV motif of the APC gene product interacts with the PDZ domain of hDLG, the human homolog of the Drosophila lethal (1) discs larige-1 (dlg) tumor suppressor. In the present study, we found that overexpression of hDLG suppresses cell proliferation by blocking cell cycle progression from the G0/G1 to S phase. This inhibition of cell cycle progression was abolished when the PDZ, SH3 or guanylate kinase-like domain of hDLG was mutated."
                   dc:creator="Marja"
                   dc:date="Thu, 12 Oct 2006 14:20:56 GMT">
    <bm:recalls RDF:resource="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10656683&amp;dopt=Abstract"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_13_01_GMT"/>
  </bm:Bookmark>
  <bm:Bookmark RDF:about="http://www.annotea.org/AnnoteaURI/bookmark/Wed_01_Nov_2006_03_25_00_GMT"
                   a:created="Wed, 01 Nov 2006 03:24:49 GMT"
                   dc:creator="Marja"
                   dc:title="BioCarta - Hypoxia and p53"
                   dc:description="Hypoxia and p53 in the Cardiovascular system"
                   dc:date="Thu, 02 Nov 2006 21:12:33 GMT">
    <bm:recalls RDF:resource="http://www.biocarta.com/pathfiles/h_p53hypoxiaPathway.asp"/>
    <foaf:maker RDF:resource="http://www.annotea.org/marja#marja"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Thu_12_Oct_2006_14_26_57_GMT"/>
    <bm:hasTopic RDF:resource="http://www.annotea.org/AnnoteaURI/topic/Wed_01_Nov_2006_01_58_41_GMT"/>
  </bm:Bookmark>
</RDF:RDF>